API TR 412 and 414 PDF download

A Range Finding Developmental Inhalation Toxicity Study of Unleaded Gasoline Vapor Condensate in Rats and Mice via Whole Body Exposures

API TR 412 and 414 – A Range Finding Developmental Inhalation Toxicity Study of Unleaded Gasoline Vapor Condensate in Rats and Mice via Whole Body Exposures

This two-part inhalation study sought to specifically evaluate the potential of unleaded gasoline fordevelopmental toxicity in rodents. The composition of the unleaded gasoline vapor condensate andthe treatment pattern used are representative of real-world exposure conditions encountered atservice stations and in other occupational settings. The results show that developmentally there were no differences between treated and control groups in malformations, total variations, resorptions, fetal body weight, or viability. Under the conditions of the study, unleaded gasoline vapors did not produce evidence of developmental toxicity. (This volume includes publications TR 412 and TR 414.)